A Better Pace

Improving your heart’s efficiency

Our Harmony™ System was designed for heart failure patients and is a minimally invasive neuromodulation implant supplies precise and personalized aortic stimulation, while the wearable unit allows the user to switch the therapy on or off, as needed.

The Harmony System can be implanted in 30 minutes in a standard catheterization procedure, without the need for general anesthesia.

Communicating Antenna

Rechargeable Battery

Aortic Implant

target antenna
target aortic
target battery
What is heart failure?

Heart failure is a condition that develops when your heart is unable to pump enough blood around the body properly. When your heart has less pumping power, there is an increase in pressure in the heart and lungs, fluid may build up in or around your lungs and causing congestion and making it hard to breathe during activities or even when at rest. Heart failure may not cause symptoms right away. But eventually, you may feel tired, short of breath and notice fluid buildup in your lower body, around your stomach, or your neck.
Heart failure means that Your heart just needs some support to help it work better

Heart failure with preserved ejection fraction (HFpEF), also referred to as diastolic heart failure, causes almost one-half of the 5 million cases of heart failure in the United States and continues to increase in the developed world.

HFpEF is a clinical syndrome in which patients have signs and symptoms of Heart failure as the result of high left ventricular (LV) filling pressure despite normal or near normal LV ejection fraction (LVEF; ≥50 percent). It is more common among older patients and women and can be measured by echocardiography or cardiac catheterization.

The first step in the diagnosis of HFpEF is recognition of possible heart failure and subsequent referral for two-dimensional transthoracic echocardiography (TTE) to confirm the diagnosis. The diagnosis of HFpEF requires clinical symptoms and/or signs of heart failure, as well as evidence of preserved LVEF and diastolic dysfunction.

Hypertension hyperlipidemia, older age, female sex, diabetes, smoking, obstructive, sleep apnea, obesity, metabolic syndrome, and sedentary lifestyle have been identified as important risk factors for diverse types of heart disease, including HFpEF.

People who have heart failure may have the following symptoms

The Harmony™ System

Implanted Unit

This "stent-like" unit delivers electrical stimulation to the aorta's inner wall.

Battery-free, the implant contains a miniature, sealed neurostimulator, a receiving RF antenna, and dedicated electrodes.

Wearable Unit

This external unit powers and communicates the the implant during neuromodulation therapy.

It contains a transmitting RF antenna and a control unit that stores the stimulation regime

Physician Unit

This unit enables wireless communication with the implant, to set the stimulation regime, and enables physicians to adjust therapy according to each patient's needs

It contains a miniature stationary unit with a wireless communication antenna.
The Harmony System is limited for investigational use only.

During my acquaintance with the Enopace team, they have been efficient, professional and organized. They have my warm recommendation.

Israel Israely, MD,
Rambam Hospital

We Believe

We believe that life is not just about
living longer but how you live it!

We believe each person and patient is unique.

We believe each person and patient needs a therapeutic product or technology that can be personalized to their condition.


Voted #1 medical innovation company, annual Shark Tank Innovation Competition, Transcatheter Interventional Therapeutics (TCT) Congress, Denver, Colorado.

Management Team

David Katz
Yoav Katz
Erez Adunsky
Director of Operations & Manufacturing

Board of Directors

David Steinhaus, MD
Executive Chairman
Ilan Neugarten
Rainbow Medical
Yossi Gross
Rainbow Medical
Guy Ezekiel, MD
Pitango HealthTech
Susan Lin
Jiawen Shen
China Universal Life Science Investment Capital

Scientific Advisers

Prof. Dan Burkhoff, MD, PhD
Prof. Andrew Coats, MD

Contact Us



    Enopace Biomedical Ltd.

    5 Tarshish St.
    Business Park, North
    P.O.B 3546 Caesarea 3079821, Israel

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